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Volume 11, Issue 3 (Vol.11 No.3 Oct 2022)
rbmb.net 2022, 11(3): 524-531 |
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Nazar Hasan Anber Z, Oead Mohammed Saleh B, Al-obidy M. Hepatocellular Damage and Severity of COVID-19 Infection in Iraqi Patients: A Biochemical Study. rbmb.net 2022; 11 (3) :524-531
URL: http://rbmb.net/article-1-916-en.html
URL: http://rbmb.net/article-1-916-en.html
Clinical Biochemistry, Department of Pharmacy, Baghdad College of Medical Sciences, Baghdad, Iraq.
Abstract: (1236 Views)
Background: Infection with COVID-19 can cause hepatic damages. Here, we aimed to examine the effect of COVID-19 infection on the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, and procalcitonin (PCT) concentrations as markers to evaluate the liver function.
Methods: In this study, 56 patients infected with COVID- 19 and 28 healthy controls was recruited in Private Nursing Home Hospital of the Medical City, Baghdad. Patients were subdivided according to disease severity into severe and non-severe groups.
Results: The results showed that the mean±SD value of serum AST activity and serum PCT concentrations were elevated significantly in severe group in comparison to healthy control, (p< 0.01, p< 0.001) respectively. Also, the mean ±SD value of serum ALT activity was higher in severe group compared to the healthy subjects and non-severe ones, significantly (p< 0.0001, p< 0.003) respectively. While the mean value of serum albumin concentration of severe patients and non-severe group were significantly decreased compared to healthy subjects. The receiver operating characteristic curve (ROC) revealed that ROC value of albumin (0.992) differentiates between non- severe infected patients and healthy subjects, while the ROC value of serum ALT activity (0.735) differentiates between severe COVID-19 patients and non- severe ones.
Conclusions: Changes of liver function parameters in COVID-19 patients were mild to moderate and measurement of serum ALT activity is the best biomarker in differentiation between non-severe patients and severe ones and albumin concentration is excellent in discrimination between patients and controls
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2022/04/13 | Accepted: 2022/04/24 | Published: 2022/12/31
Received: 2022/04/13 | Accepted: 2022/04/24 | Published: 2022/12/31
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